The ACE Registry
The Ace Registry, a PrecisionMed - CDR (www.cdr.org.uk) collaboration, is a biological sample bank of serial DNA, RNA, CSF, serum, plasma and urine associated with linked serial cognition data, based on a cognition battery selected from CDR's proprietary computerized testing platform.
Memory deficit is a natural and persistent phenomenon of the aging process. A better understanding of the underlying biology of memory and memory disorder is essential for the development of accurate diagnostic biomarkers and more effective treatments.
A significant problem in the evaluation of cognition deficit in initially normal and more importantly, impaired subjects, is failure to establish a reliable baseline score. Ratings in clinical research are often based on relatively few repeated measurements taken over a short period of time and often by different raters. The ACE Registry will establish robust baseline cognition scores using the same validated instrument every 6 months. In addition, by introducing reliable and validated computerized cognitive assessments, The ACE Registry also seeks to remedy some of the other cognition evaluation shortcomings. Declines in cognition will be quantified with reference to a stable baseline.
To qualify for the study, subjects will necessarily exhibit normal memory function within the normal range on the CDR word recognition task.
Biological samples will be banked by PrecisionMed and clinical data will be stored at PrecisionMed. Coded serial blood and CSF samples with linked serial clinical and cognition databases will be marketed to the pharmaceutical and biotechnology industries. Participating organizations will receive biological samples linked to clinical data with the results of cognitive testing. Subject identifiers will be stored in a separate database and will not be supplied to participants
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ACE Registry Press Release
ACE Registry Slide Show
ACE Registry Recruitment Update
ACE Registry Interim Report
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