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CSF Overview
The PrecisionMed CSF biorepository consists of CSF, DNA, PAXGene, serum and plasma collections from diseased and normal control subjects, with associated detailed clinical data corresponding to each donor visit. Collections of diseased and normal control CSF comprise samples from various age groups and visit formats. New subjects, repeat visits for existing subjects as well as additional disease types are regularly added. All CSF is collected under IRB approved protocols. PrecisionMed performs custom CSF collections and custom CSF processing.
Our normal CSF is from donors with normal cognition, no history and no family history of neurological or neuropsychiatric disease and no neurological complaint.
Our CSF inventory changes daily – for a detailed, current CSF inventory contact us here for a quote.
Normal CSF Donors > 60 years old
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The ACE (Aging Cognition Evaluation) Registry | Protocol 7009
Ongoing
The Ace Registry, a PrecisionMed – UBC (http://www.unitedbiosource.com/) collaboration, is a biological sample bank of serial DNA, RNA, CSF, serum and plasma associated with linked serial cognition data, based on a cognition battery selected from UBC’s proprietary computerized testing platform.
Memory deficit is a natural and persistent phenomenon of the aging process. A better understanding of the underlying biology of memory and memory disorder is essential for the development of accurate diagnostic biomarkers and more effective treatments.
A significant problem in the evaluation of cognition deficit in initially normal and more importantly, cognitively impaired subjects, is failure to establish a reliable baseline score. Ratings in clinical research are often based on relatively few repeated measurements taken over a short period of time and often by different raters. The ACE Registry establishes robust baseline cognition scores using the same validated instrument every 6 months. In addition, by introducing reliable and validated computerized cognitive assessments, The ACE Registry also seeks to remedy some of the other cognition evaluation shortcomings. Declines in cognition are quantified with reference to a stable baseline.
To qualify for the study, subjects must exhibit normal memory function within the normal range on the CDR (UBC) word recognition task. Biological samples are banked by PrecisionMed and clinical data are stored at PrecisionMed. Coded serial blood and CSF (optional) samples with linked serial clinical and cognition data are marketed to the pharmaceutical and biotechnology industries. Participating organizations receive biological samples linked to clinical data with the results of cognition testing. Subject identifiers are stored in a separate database and are not supplied to customers . The ACE Registry is ongoing and has samples available for purchase.
ACE Registry Slide Presentation (PDF)
CSF, DNA, PAXGene, serum and plasma -
Elderly Control Protocol 7800
Completed | 21 Donors | Over 60 y/o with CSF
Protocol 7800 is a collection of CSF and blood products from donors mostly aged >60 years. Each donor has donated samples on 2 occasions 4-12 weeks apart. This collection is completed and has samples available for purchase.
CSF, DNA, PAXGene, serum and plasma
Normal CSF Donors < 60 years old
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Elderly Control Protocol 7800
Completed | 19 Donors | <60y/o with CSF
Protocol 7800 is a collection of CSF and blood products from donors mostly aged >60 years, however there are additional donors who are younger than 60 years old. Each donor has donated samples on 2 occasions 4-8 weeks apart. This collection is completed and has samples available for purchase.
CSF, DNA, PAXGene, serum and plasma -
Normal Controls from Schizophrenia Collection Protocol 1022
Completed | 25 Donors with CSF
Protocol 1022 is a collection of CSF and blood products from donors aged <60 years. These normal subjects were collected as normal controls for a collection of CSF and blood in donors diagnosed with Schizophrenia. Each donor has donated samples on 2 occasions 4-8 weeks apart. This collection is completed and has samples available for purchase.
CSF, DNA, PAXGene, serum and plasma
Normal CSF Donors < 35 years old
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Young Controls Protocol 7900
Completed | 14 Donors with CSF
Protocol 7900 is a collection of CSF and blood products from donors aged <35 years. Each donor has donated samples including CSF and blood on 5 occasions over 24 hours. This collection is completed and has samples available for purchase.
CSF, DNA, PAXGene, serum and plasma
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Young Controls Protocol 8500
Completed | 30 Donors with CSF
Protocol 8500 is a collection of CSF and blood products from non smoking donors aged <35 years. Each donor has donated samples including CSF on 3 occasions over 40 hours, Blood draws were more frequent. This collection is completed and has samples available for purchase. Thirty normal non smoking subjects were enrolled into this protocol.
CSF, DNA, PAXGene, serum and plasma
Normal CSF Donors > 18 years old
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Young Controls Protocol 7005
Ongoing
Protocol 7005 is a collection of CSF and blood products from donors aged > 18 years. Each donor donates samples including CSF and blood on 3 occasions 4-6 weeks apart. This collection is ongoing and has samples available for purchase.
CSF, DNA, PAXGene, serum and plasma
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Banked and ongoing Diseased CSF collections
Our diseased CSF biorepository comprises the following diagnoses: Alzheimer’s Disease (AD), Mild Cognitive Impairment (MCI), Parkinson’s Disease (PD), Schizophrenia and Multiple Sclerosis (MS).
Alzheimer's Disease
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AD Single Site CSF Collection
Single Academic Site | Ongoing
PrecisionMed is pleased to announce the availability of CSF and plasma from a single academic site collection of 100 donors including Alzheimer’s disease, mild cognitive impairment and normal, appropriately aged controls. The announcement was made at The World Biomarker Congress in Philadelphia, Pennsylvania. The collection supplements the company’s biological sample bank of CSF and other biological sample types associated with neurodegenerative and neuropsychiatric disease.
This self contained single site collection of correlated data and biological samples is of value for the investigation of biomarkers related to cognitive decline, MCI, Alzheimer’s and other neurodegenerative disease. All subjects were recruited, clinically evaluated, cognitively studied, and sampled at a single academic clinical site with expertise in Alzheimer’s disease. Samples and clinical data are available immediately to researchers worldwide.
CSF, DNA, PAXGene, serum and plasma -
Alzheimer’s Disease (AD) and Mild Cognitive Impairment (MCI)
Protocol 8009 | Ongoing
The SAMPLE Registry (Serial Alzheimer’s and MCI Prospective Longitudinal Evaluation) is an ongoing collection of correlated data and biological samples (including CSF) for the investigation of biomarkers of cognitive decline. The SAMPLE Registry is enrolling subjects, with either MCI or AD, aged 50 years and older. All subjects are recruited, evaluated, cognitively studied, and sampled from 12-15 experienced investigative sites, all US based.
Enrollment is ongoing. Six monthly samples with matched clinical data are available on a longitudinal basis. Custom requests for additional sample types, as well as more complex clinical, laboratory and/or radiographic evaluations within selected subpopulations will be entertained. The SAMPLE Registry will enroll at least 200 subjects, with either MCI or AD, aged 50 years and older. Enrollment began in August, 2007.
Key aspects of subjects’ cognition including memory and attention are evaluated every six months with simultaneous biological sampling of CSF and blood for a period of 5 or more years.
Six monthly samples with matched clinical data are available on a longitudinal basis. The longitudinal clinical data collected in the AD and MCI subjects over the length of this study to date indicates that the MMSE scores tend to decrease and the ADAS-Cog scores tend to increase over time in both sub-groups (See slide presentation).
SAMPLE Registry Slide Presentation (PDF)
SAMPLE Registry Press Release
SAMPLE Registry Poster
CSF, DNA, PAXGene, serum and plasma
Parkinson's Disease
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Parkinson’s Disease Protocol 1009
Ongoing
Subjects must have been diagnosed with Parkinson’s disease for at least 1 year and must be on and have responded to a stable dose of dopamine therapy for at least 6 months. Onset of Parkinson’s disease must have been at age 60 or older. Subjects with neurological disease (other than Parkinson’s) are excluded.
CSF, DNA, PAXGene, serum and plasma
Multiple Sclerosis
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Multiple Sclerosis (MS) and Clinically Isolated Syndrome (CIS) Protocol 5400
Ongoing
The Multiple Sclerosis Registry is an ongoing collection of correlated data and biological samples (including CSF) from subjects diagnosed with Multiple Sclerosis or Clinically Isolated Syndrome. The MS Registry is enrolling subjects with Definite Multiple Sclerosis, Relapsing Remitting, Chronic Progressive or Secondary Progressive or Clinically Isolated Syndrome.
Six monthly samples with matched clinical data are available on a longitudinal basis. Custom requests for additional sample types, as well as more complex clinical, laboratory and/or radiographic evaluations within selected subpopulations will be entertained as the registry matures.
CSF, DNA, PAXGene, serum and plasma
Schizophrenia
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Schizophrenia Protocol 1022
Completed | 54 Donors with CSF
The schizophrenia CSF collection is complete and comprises 54 subjects with CSF. Most subjects have 2 CSF draws 4-8 weeks apart. We have matched control CSF available for most subjects.
Donors have detailed demographic information, including medications, family history and rating scales such as the PANSS as well as the M.I.N.I or S.C.I.D. and cognition/memory testing.
Subjects met the DSM-IV diagnostic criteria for schizophrenia and schizoaffective disorder as defined in the DSM-IV (295.10, 295.20, 295.30, 295.60, 295.90, 295.70). Diagnosis is confirmed by a psychiatrist. Subjects with evidence or current history of substance abuse were excluded.
CSF, DNA, PAXGene, serum and plasma
Custom CSF Collections and Processing
PrecisionMed performs custom CSF Collections and Processing. The ongoing IRB approved 7005 (aged 20-80) protocol allows PrecisionMed to rapidly perform custom CSF collection and processing in normal donors.
PrecisionMed also designs and conducts custom CSF collections in diseased populations.
